Antioxidants & Neuroprotectives

Tianeptine Sulfate: Benefits, Dosing, Side Effects, And More!

Typical daily doses of Tianeptine Sulfate range from 12 to 36 mg
Synthetic NootropicsSerotonergics
Erik Abramowitz, FNTP
Reviewed by Erik Abramowitz, FNTP Last updated February 5, 2026
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Overview

Tianeptine Sulfate is a synthetic compound primarily used as an antidepressant and anxiolytic. It is known for its unique mechanism of action, which enhances serotonin uptake and has neuroprotective properties, making it a subject of interest in nootropic research.

Dosage

Typical daily doses of Tianeptine Sulfate range from 12 to 36 mg, often taken in divided doses throughout the day. It is generally recommended to take it on an empty stomach for optimal absorption.

Research & Studies

This section includes 3 peer-reviewed studies referenced in our analysis.

Neurobiological and clinical effects of the antidepressant tianeptine.

2008DOI: 10.2165/00023210-200822010-00002
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Effect of tianeptine on cognitive functions in patients with depressive disorders during a 3-month observation.

2011
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Tianeptine Enhances Energy-related Processes in the Hippocampal Non-synaptic Mitochondria in a Rat Model of Depression.

2021DOI: 10.1016/j.neuroscience.2020.09.061
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Medical Disclaimer: This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare provider before starting any supplement regimen.
Reference ID: 1975 Updated: Feb 5, 2026