Cholinergics

Sunifiram: Benefits, Dosing, Side Effects, And More!

Typical daily doses of Sunifiram range from 5 to 20 mg
Synthetic NootropicsRacetams
Erik Abramowitz, FNTP
Reviewed by Erik Abramowitz, FNTP Last updated February 5, 2026
Regulatory Warning: This substance is subject to active FDA enforcement action, has been involved in federal criminal prosecutions, or is classified as unsafe for sale as a dietary supplement. This page is retained for educational and harm-reduction purposes only. Do not purchase or consume this substance based on information found here.

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Overview

Sunifiram is a synthetic nootropic compound belonging to the racetam family. It is primarily used for its potential cognitive-enhancing effects, including improved memory, learning, and focus.

Dosage

Typical daily doses of Sunifiram range from 5 to 20 mg, often taken once or twice a day. It is generally recommended to take it on an empty stomach for optimal absorption.

Research & Studies

This section includes 4 peer-reviewed studies referenced in our analysis.

DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer.

2002DOI: 10.1007/s00210-002-0577-3
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Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers.

2006DOI: 10.1111/j.1527-3458.2006.00039.x
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Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice.

2013DOI: 10.1016/j.bbr.2012.12.054
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Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor.

2014DOI: 10.1002/hipo.22150
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Medical Disclaimer: This information is for educational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a qualified healthcare provider before starting any supplement regimen.
Reference ID: 1033 Updated: Feb 5, 2026